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Medical interventions, such as ovulation-inducing medications, may be necessary in some cases

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Individual variation in GLP-1 receptor expression and gastric motility means some patients tolerate dose escalation smoothly while others experience persistent diarrhea

Most patients reach stable weight loss or plateau within 46 months of therapy

Avoid Anti-Inflammatories: Skip NSAIDs for one week, as inflammation helps break down fat cells

DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors are included as options for combination therapy with metformin for patients who require dual therapy to meet glycemic goals