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This is likely to be an issue in G6PD-deficient individuals because an inability to maintain endothelial homeostasis has been linked to both acute and chronic inflammatory endothelial activation and has relevance to pathologies as diverse as cardiovascular disease and sepsis

Nrf2-related pathways are mainly AKT-GSK3-Nrf2-ARE, MKLP2-APK5/PP1-GSK3-Nrf2, KEAP1-Nrf2

Oncogene (2004) 23:244253.10.1038/sj.onc.1207358 17 FujiiJIuchiYOkadaF

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Avoid the area directly around the navel (within 1 inch)