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What we know comes from preclinical toxicology and post-market surveillance of compounded products

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Concentration and syringe markings must match written instructions

Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

study used micromolar concentrations in vitro, which corresponds roughly to this topical range when accounting for skin penetration dynamics

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