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Notably, metformin can directly upregulate GLP-1R expression in pancreatic cells 29,30,31

Across major GLP-1 trialsincluding the STEP trials for weight loss and multiple cardiovascular outcome trialsirritability, anger, or aggression were not common adverse events, and rates were similar to placebo groups

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5e), at variance with what was reported previously for high concentrations of the peptide in both mouse and human islets [41, 42]