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DSIP-CBBBP Fusion Peptide BBB Delivery Research (2024) The 2024 Frontiers in Pharmacology study by Shao and colleagues investigated a DSIP-CBBBP (cell-penetrating peptide) fusion construct expressed in Pichia pastoris in a PCPA-induced insomnia mouse model

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5,6 In addition, receptor activator of nuclear factor kappa beta ligand (RANKL), that plays a crucial role in osteoclast activity and bone resorption, 21 also directly influences pancreatic beta-cell function and overall metabolism, with its activity being compromised in obesity and T2D

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