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6.1 Potential Benefits for HRT Patients For patients undergoing hormone replacement therapy, the benefits of semaglutide extend beyond its primary indications of diabetes management and weight loss

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Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig

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Researchers used TriNetX a global health research network that aggregates deidentified data from more than 275 million people to identify individuals for the study