The DNA damage caused by UV mainly affects the electronic structure of DNA by promoting chemical reactions between bases, especially the dimerization of thymine (cyclobutane derivative) [2]
It is an orally administered, selective nuclear translocation inhibitor that binds specifically and reversibly to CRM1 (exportin 1, XPO1) at cysteine residue 528
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Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice
Individuals with obesity are at elevated risks of diabetes, cerebrovascular disease, and solid cancer
In an open-label, phase 3, multicenter study involving 11 children aged 25 years with biallelic POMC, PCSK1, or LEPR variants, or genetically confirmed BardetBiedl syndrome (BBS), 83% achieved a 0.2-point reduction in BMI Z score over 52 weeks, with a mean BMI reduction of 18% observed overall (26% in the POMC/LEPR group and 10% in the BBS group) [45]
