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Similar in molecular structure to insulin, IGF-1 plays a role in growth during childhood and continues later in life to have anabolic, as well as neurotrophic effects

As permeant ion channel blockers of AMPARs and KARs, cytoplasmic polyamines (spermine, spermidine, putrescine) have been identified as critical modulators of neuronal signaling, influencing action potential firing rates as well as the efficacy of neurotransmission (Nichols and Lopatin, 1997)

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ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288

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