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For example, ROS can mutate the MTHFR gene, reducing Hcy conversion to methionine and raising Hcy levels

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There is sufficient evidence to show that depletion of GSH in platelets results in increased platelet adhesion and aggregation, and that exogenous GSH supplementation may inhibit platelet activation

In addition, these cells failed to accumulate ROS in response to arsenic treatment, in contrast to their arsenic-sensitive parental cells, unless cotreated with buthionine sulfoximine