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This 72-week study compared the efficacy and safety of subcutaneous semaglutide 7.2 mg against semaglutide 2.4 mg and a placebo, all administered weekly, in 1,407 adults with obesity who also participated in lifestyle interventions
Two further notes
The initial phase is, to a large extent, driven by reward ( 2.2 Several GLP-1R-containing brain regions regulate alcohol-mediated responses in rodents After systemic injections of the aforementioned GLP-1R agonists, the roles of central and peripheral receptors cannot be distinguished
In the context of GLP-1 injections, microdosing describes using a fraction of the usual dosea concept borrowed from the world of psychedelics, where the term means taking minuscule, sub-perceptual amounts of substances like LSD
International Journal of Obesity , 33(9), 956961
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