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Alright, let's get to the heart of it

(Shanghai) 44 , 623 (2012)

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Auranofin shows an additive effect with COJEC chemotherapy Because the antagonism observed between RSL3 and COJEC appears to be mediated by GPX4 upregulation, we decided to test COJEC in combination with a ferroptosis-inducing agent with a different MOA, the TrxR inhibitor Auranofin

JQ1 is an inhibitor selective for the bromodomain and extra-terminal (BET) family members, such as BRD4, of the larger class of bromodomain-containing proteins (BCPs), which recognize acetylated lysine residues, a common epigenetic mark 16