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One thing practitioners will consistently mention is GHK-Cu can lead to a stinging sensation upon injection

(PubMed) Clarke R, Harrison G, Richards S

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A bent needle tip has a barbed microscopic edge that tears tissue rather than piercing cleanly, creating unnecessary trauma, prolonged injection site tenderness, and increased infection risk from irregular wound geometry

doi: 10.1016/j.theriogenology.2015.10.009, 43