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The field is moving fast, perhaps faster than the safety data can accumulate

Patients often tell me they feel fine on their first consultation, only to recognise in hindsight, once their B12 has been corrected, that they had been running at a reduced baseline for years

10.1053/j.gastro.2012.06.031 209

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Fasted-state dosing (minimum 3 hours post-meal) ensures low somatostatin tone and maximal pituitary responsiveness