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RSL3 can directly inhibit GPX4 activity but not its precursor GSH [27]

Unlike DAA and GB, IREB2 is a key indicator of cellular ferroptosis, and increased Fe 2+ can promote ubiquitination of the IREB2 protein and suppress expression of FTH1

Enzyme Microb Technol 3:233242 Penninckx MJ (2000) A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses

Whole blood was layered on to ficoll histopaque in a 1:1 ratio and centrifuged at 25C for 30 minutes at 1800 RPM with the slow brake to prevent disturbance of the gradient

( b-d ) Immunoblot ( b ) and immunohistochemistry ( c-d ) validation of BDH1 iKO and OXCT1 iKO cohorts