GLP 1 receptor agonists addressed multiple aspects of glucose homeostasis by enhancing glucose dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and promoting satiety
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In published Phase 2 clinical studies, retatrutide was evaluated using once-weekly dosing schedules , with doses escalating up to 12 mg over a 48-week treatment period
doi: 10.3390/ijms21010140
