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Autoantibodies against the folate receptor alpha (FR) are found in over 75% of children with autism, which can block folate transport into the brain

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Under such conditions, the newly absorbed folate is not retained by the tissue and is released back into the systemic circulation, mostly as 5-methyl-THF

However, similar to what we observed for strep-MBP-GRXC2, strep-MBP-HsGRX1 became oxidized already upon addition of GSH, resulting in two main protein species which persisted over a wide range of GSH/GSSG ratios (Fig

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