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Clinicians should: Assess baseline HbA1c and current glycemic control before discontinuation Implement or intensify alternative therapies (metformin, SGLT2 inhibitors, or other agents) before or concurrent with tirzepatide cessation Increase home glucose monitoring frequency for several weeks post-discontinuation Schedule follow-up to evaluate metabolic stability Special consideration for insulin or sulfonylurea users : Patients taking these medications alongside tirzepatide may need proactive dose adjustments when stopping tirzepatide to prevent hypoglycemia

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"Two Things Most Reviews Skip" is an editorial description of those same two documented gaps, not a universal claim about every review that exists

Initial preclinical results has been supported by encouraging data from intial clinical trials, which has given rise to further clinical evaluations

Lets not look a gift horse in the mouth

Medication review: could diabetes drugs change hypoglycemia risk