Yes, you can have acanthosis nigricans on your face, including your nose, mouth, and eyelids, but this is rare.
For example: Fatigue, unexplained weight loss, or abdominal pain may indicate liver disease or cancer Easy bruising, night sweats, or feeling full quickly (early satiety) may suggest a myeloproliferative disorder Swelling in the legs, reduced urine output, or persistent nausea may point to kidney disease In cases of very high B12 from injections (not oral supplements), some people have reported headache, nausea, diarrhea, facial flushing, or skin rash
Paying attention to which specific foods cause problems allows for targeted dietary adjustments
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Nat Rev rheumatol
The advantage of propionibacteria is their ability to synthesize vitamin B 12 as well