Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a transcription factor and a central regulator of the bodys oxidative stress response 11,12 , so that activating Nrf2 holds promise as an effective therapeutic strategy in OA
Damage caused by free radicals is known as oxidation or oxidative stress
Currently available data suggest that iron overload in hemochromatosis patients is associated with PS externalization and calpain activation, typical hallmarks of eryptosis [83]
In:WirnitzerKetal., editors
485 Additionally, overexpressing ABCB8, a mitochondrial protein that promotes iron export, reduces both mitochondrial ROS and iron, improving DOX-induced cardiomyopathy
AndTP53 mutations, EGFR amplification, and replication stress-induced DNA methylation collectively downregulate RB1 expression [20, 21]