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Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a transcription factor and a central regulator of the bodys oxidative stress response 11,12 , so that activating Nrf2 holds promise as an effective therapeutic strategy in OA

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Damage caused by free radicals is known as oxidation or oxidative stress

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Currently available data suggest that iron overload in hemochromatosis patients is associated with PS externalization and calpain activation, typical hallmarks of eryptosis [83]

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In:WirnitzerKetal., editors

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485 Additionally, overexpressing ABCB8, a mitochondrial protein that promotes iron export, reduces both mitochondrial ROS and iron, improving DOX-induced cardiomyopathy

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AndTP53 mutations, EGFR amplification, and replication stress-induced DNA methylation collectively downregulate RB1 expression [20, 21]

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