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What has been abundantly clear is that inflammation is a key component of MS, also contributing to CNS atrophy and disability, particularly in the early relapsing phase

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The CN groups on the surface of Prussian blue (PB) were first reduced to -CH 2 -NH 2 , and then lithium aluminum hydride was used as a reducing agent under ice bath conditions to further form an amide bond between -CH 2 -NH 2 and the COOH group of hemin, which carried NO as an additional site (Fig