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Indeed, growing evidence suggests that women tend to achieve more pronounced glycaemic improvements and greater weight reduction when treated with GLP-1 RAs compared to men, partly explaining the more frequent initiation of GLP-1 therapy among female patients [20, 21]

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Also, the extrinsic factors of surrounding media such as PH, ionic strength and water hardness can influence the NP behavior in solution (Peretyazhko et al., 2014