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Glinides are insulin secretagogues that lack the sulfamide group of the sulfonylureas and differ from sulfonylureas in receptor affinity, binding sites, duration of action and mechanism of absorption and elimination ( According to data from several meta-analyses, an overall increased cancer risk was reported in patient using sulfonylureas compared with those treated with metformin or other diabetes medications (Wu et al., 2015

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A large observational analysis published in JAMA Psychiatry examined data from adults with alcohol use disorder and found that semaglutide reduced alcohol consumption compared to placebo, with researchers attributing the effect to the same dopaminergic dampening that appears to reduce food noise

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