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Short-acting GLP-1 RAs, exenatide and lixisenatide, are associated with a transient (112 h) mean placebo- and baseline-adjusted 24-h HR increase of 13 beats per minute (bpm)

We aimed to screen for a potential oral small-molecule GLP-1R agonist and evaluated its effect on blood glucose and NASH

Levels rise quickly but often fall just as sharply, leaving highs and lows that dont match the bodys natural design

Gradual titration (dose escalation) leads to better tolerability

In contrast, certain medications, including topiramate-containing therapies and naltrexone-bupropion, may contribute to mood changes, anxiety, or depression in some individuals

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