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Prednisone, like other corticosteroids should not be administered concomitantly with: - Barbiturates, carbamazepine, phenytoin, rifampin or ephedrine: these drugs enhance the metabolism of corticosteroids reducing their therapeutic action

However, during pregnancy, your body produces 80% MORE of the toxic NAPQI metabolite (43% higher in first trimester), sulfation capacity decreases 33%, and glutathione depletes 36-87%

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Behav Med (2011) 37(3):10512