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Patients with a history of hypersensitivity reaction to other GLP-1 receptor agonist should not be started on semaglutide

BPC-157 addresses this by restoring tight junctions between intestinal cells, reinforcing the selective barrier that normally controls what enters circulation from the digestive tract

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R.RiessH.et al (2015)

Upon injection, it binds directly to GLP-1 receptors located in the brain's satiety centers, drastically reducing hunger signals and putting an end to compulsive psychological cravings

NIH and Office of Dietary Supplements grants HL103866, HL126827, and DK106000, and the Leducq Foundation