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247 The primary action often occurs through indirect mechanisms, such as insulin and somatostatin

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This study had some limitations

(5) PRODH in the regulation of ferroptosis Potential links between proline metabolism and ferroptosis PRODH is a mitochondrial enzyme primarily responsible for the oxidation of proline to P5C as part of amino acid catabolism and redox metabolism 101

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While showing promising anti-aging effects, the review emphasizes that long-term safety and efficacy for healthy aging still require more research