Daily observations: Appetite level (1-10 scale), nausea level (0-5 scale), energy level, any notable GI symptoms, bowel changes, mood or sleep changes
Easy to forget that the appetite we are silencing is not only biologicalit is human
Each tier tells a distinct story about efficacy, tolerability, and the tradeoffs researchers face when selecting a protocol
We titrate slowly to improve comfort and sustainability
Costco pharmacy sometimes offers lower retail prices on GLP-1 medications than other retail pharmacies, but the savings are modest compared to manufacturer direct programs
Tirzepatide also reduces liver fat, with studies showing meaningful improvements, but the magnitude does not approach what retatrutide achieves