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Using gene-edited mice with humanised GLP-1 receptors, the team found that oral small-molecule GLP-1 drugs activated the central amygdala, a region associated with desire and reward that sits deeper in the brain than the hypothalamic and hindbrain networks where injectable peptide GLP-1s have been shown to act
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This double-blind, placebo-controlled study randomized adults with a BMI 30 or 27 plus at least one obesity-related comorbidity (excluding diabetes) who had achieved 5% weight loss after 12 weeks of lifestyle modification to receive tirzepatide or placebo weekly for 72 weeks
Zhuang, Yanli, Zhenhua Xu, Bart Frederick, Dick E
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BPC-157, often called the Body Protection Compound, is a key component of the stack
