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Activity of IMMU-130 anti-CEACAM5-SN-38 antibody-drug conjugate (ADC) on metastatic colorectal cancer (mCRC) having relapsed after CPT-11: Phase I study

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they share the common properties of increasing brain glutamate concentration and neurotransmission and of activating rCMRglc in frontal areas and subcortical aminergic nuclei (Toth et al., 1993