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According to Kannt & Pfenninger in Frontiers in Physiology , NAD is a critical coenzyme in mitochondrial energy metabolism, and strategies that preserve NAD have wide-ranging effects on health and performance (Kannt & Pfenninger, Frontiers in Physiology )
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Pregnancy hormones soften ligaments, changing center of gravity shifts posture, additional weight stresses spinal structures, and the growing uterus can directly compress the sciatic nerve
Sustained inhibition could have tissue-specific effects that short animal experiments do not fully capture
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