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J Biol Chem 179:12451254 Carmel-Harel O, Storz G (2000) Roles of the glutathione- and thioredoxin-dependent reduction systems in the Escherichia coli and Saccharomyces cerevisiae responses to oxidative stress

Side effects tied to peak concentration (nausea, vomiting) might be slightly reduced with split dosing, which is why some patients on compounded tirzepatide do split their weekly dose into two mid-week injections during titration

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