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NCDs, non-communicable diseases

Along with a significant pool of preclinical data on the effect of GLP-1RAs (including exendin-4) on PD models in experimental animals, showing a decrease in the loss of dopaminergic neurons and accumulation of -synuclein in the brain, a decrease in mitochondrial dysfunction and expression of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and interleukin IL-1 [61], promising data from clinical studies on the use of GLP-1RAs in PD have been obtained [62]

Avoid indefinite restriction without reintroduction

(XLSX 11 KB) 299_2021_2717_MOESM3_ESM.xlsx (download XLSX Supplementary file3 Supplementary Table S3 Domain organization of GR proteins in Aegilops tauschii , Brachypodium distachyon , Sorghum bicolor , Tritricum aestivum and Triticum urartu and motif sequences

After accounting for progression to diabetes, people with prediabetes had an elevated long-term risk of complications: 85% (95% CI 75, 94) of the excess prediabetes risk remained for any complication (composite outcome)

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