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GLP-1RAs improve glucose uptake in cardiomyocytes through dual mechanisms: triggering AMPK activation to facilitate GLUT4 translocation to the cell membrane and regulating the insulin signaling pathway to upregulate GLUT4 expression (79, 80)

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Apple polyphenols extract alleviated dextran sulfate sodium-induced ulcerative colitis in C57BL/6 male mice by restoring bile acid metabolism disorder and gut microbiota dysbiosis