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In addition, NaB treatment induced GLP-1R expression in human HepG2 cells and markedly reversed the FFA-induced downregulation of GLP-1R expression but not the expression of TNF- or lipopolysaccharide in vitro (Fig

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In contrast, we found that these metabolomic alterations led to a reduction in the plasma level of different metabolites including uridine, thymine, carnosine, theophylline, aspartate, taurine, serine, glutamate, tryptophan, arginine, and 53 other metabolites in the acute patients compared to HCs ( Supplementary Figures 6A, B )

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