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Analyses of the effects of FFA (NEFA) on macrophages in cell culture demonstrated that they can activate inflammatory signaling through the toll-like receptors (TLR), specifically TLR4

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The author and planners of this CNE activity have disclosed no relevant financial relationships with any commercial companies pertaining to this activity

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PAGln induces hypercontractility and altered Ca 2+ handling in cardiomyocytes The above physiological responses suggest that despite the lack of cardiac dysfunction as measured by echocardiography, there is a central effect of PAGln on the ability of the myocardium to contract and relax properly, manifesting as an elevation in LVEDP despite no change in afterload