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WritingOriginal draft preparation: M.E.H.K
The activation of GPER has been reported to stimulate the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [121, 122], resulting in the upregulation of the expression of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) [123]
Behavioral changes are measured in tests that allow predictive assessment in specific contexts
In the 24-week trial of patients receiving sitagliptin as add-on combination therapy with metformin, there were no adverse reactions reported in 5% of patients and more commonly than in patients given placebo
[11] [12] In the NHS, access to these medicines is subject to specific eligibility criteria set out in NICE technology appraisals (e
