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Titration schedules exist because moving faster raises the chance of gastrointestinal side effects without a guaranteed payoff, and because the maximum dose is a maximum

Most RCTs failed to demonstrate a significant association between GLP-1 RAs and the occurrence of pancreatitis or pancreatic cancer, primarily because of their short duration and insufficient design for evaluating such risks

In February, he was awarded Israels prestigious Wolf Prize for work on diabetes

(2025, August 15)

This study shows that as new medications are approved we need to be careful as long term side-effects may be seen that we were not aware of. Diabetes is very common in our practices and many of our patients are put on the GPL-1s, Geffen continued

Other reported effects include fatigue, headaches, dizziness, and injection site reactions for injectable formulations