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It will determine whether retatrutide produces a reduction in major adverse cardiovascular events (MACE) comparable to or greater than the SELECT trial result for semaglutide (20% reduction)

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The 2025 Aesthetic Surgery Journal Open Forum paper by Semersky et al

This happens because certain bacteria in the gut break down carnitine into a compound called trimethylamine (TMA)

After bacteria adhere to the damaged endothelium, platelets and fibrin are deposited over the organisms, leading to the formation of a vegetation

Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL,Jr