Additionally, GLP-1 RAs can modulate appetite-regulating centers in the hypothalamus, such as directly activating POMC neurons [63] or inhibiting AgRP neurons by acting on GLP-1R-expressing neurons in the dorsomedial hypothalamus [61,63]
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Specifically, we demonstrated that GLP-1MK-801, but not the parent GLP-1 analogue, suppressed NMDA-induced inward currents (Extended Data Fig
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The adverse effects of GLP-1RA, such as nausea, constipation, and diarrhea, are thought to be the result of the pharmacological action of GLP-1, but the mechanisms have not been fully elucidated