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Os benefcios mais bem documentados nos estudos pr-clnicos incluem: acelerao da cicatrizao de tendes e ligamentos (com melhora das propriedades biomecnicas), proteo da mucosa gstrica contra AINEs e lcool (reduo de 78% da superfcie ulcerosa em modelos animais), estimulao da angiognese via VEGF, e efeitos neuroprotetores em modelos de leso cerebral

[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy

We attribute this broadening to the natural change in the mechanical anchorage of bonds over contact time

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