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Its important to remember that these are not the only possible side effects

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Pellets were resuspended in 100 mM triethylammonium bicarbonate buffer, digested with trypsin (37 C, overnight), then lyophilized

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Like many of the acutely symptomatic tears, bucket handle tears are typically caused by trauma, usually a sporting injury, that occurs when the patient is twisting or pivoting their leg while trying to abruptly change direction