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Advantages include long shelf life when stored properly (below -20C)

Mechanism and Factors Involved: Because of the many physical and chemical manipulations required in upstream production and downstream processing, followed by formulation and filling operations, aggregation of protein biopharmaceuticals can be induced during nearly every step of the process including at hold points, shipping, and long-term storage (16,21)

80 DSBs that are typically caused by IR are repaired by nonhomologous end joining (NHEJ) or by homologous recombination (HR)

Add 3.0 mL bacteriostatic water to one 1 mg vial ~0.333 mg/mL (333 mcg/mL), a large dilution chosen for accurate low-dose measuring

doi: 10.1016/j.jcot.2023.102278 13

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes