NMN supplementation upregulates NNMT (nicotinamide N-methyltransferase), which consumes SAM (S-adenosylmethionine) methyl groups
I want to thank Todd Payne of Cleveland Hopkins Airport for his kind assistance with providing imagery.
note the peptide's favorable tolerability profile across multiple rodent studies, with no reported organ toxicity at research doses [1,2]
Secondly, GLP-1 receptor agonists carry important safety considerations including risk of pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (based on rodent studies, though human relevance remains uncertain)
The Journal of Pharmacology and Experimental Therapeutics issued an Expression of Concern in 2021 (PMID: 34551989) for the McCoy et al
Headache: Occasional, typically transient