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Likewise, L-NAME responsive, L-arginine responsive, parallel beneficial effect NO-response might combine the recovered acute amphetamine-induced effects as the resembling positive-like symptom [70] and ketamine-prolonged exploration time in the ketamine-induced cognition dysfunction as the resembling negative-like symptom [59]

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Repeated-dose studies in rats, dogs, and mice for up to 6 weeks across various routes showed excellent tolerance with minimal adverse findings