Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide
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Calculation Glutathione concentration was calculated in mmol/g protein unit
Randomised clinical trials have demonstrated very low rates of hypoglycaemia with GLP-1 RAs when used as a monotherapy or in a combination therapy with other glucose-lowering drugs [16, 18, 20, 22, 24, 26, 28]
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