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By this point scientists had already begun to realise that insulin deficiency by itself was insufficient to cause diabetes and may also require the presence of glucagon

Key hormonal changes associated with weight loss include: Decreased leptin signalling to the hypothalamus Reduced oestrogen production from adipose tissue Alterations in insulin sensitivity and androgen levels These metabolic and hormonal adaptations are the body's way of conserving energy during perceived scarcity, but they can temporarily disrupt normal reproductive function

However, many patients tolerate the medication well when dosing is careful and progressive

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Instead, work with your PlexusDx team to slow your dose increase, maintain your current dose longer, or switch to an alternative GLP-1 compound like tirzepatide if joint symptoms persist