KRK received funding to perform metabolomics mass spectrometry analysis, which was funded by a research grant from FWO (FWO KAN2018 871 1501419N), further experiments were supported by the KNAW early career award 2022 and FEBS excellence award 2022 (to KRK)
doi:10.1136/rapm-2020-102088 Aranow C, Atish-Fregoso Y, Lesser M, et al
Glutamine is a neutral amino acid and thus does not induce a negative charge burden in the mitochondrial matrix, which is already more negatively charged than the cytosol
These further studies may enhance the clinical applicability of CPP-CAND and contribute to the treatment of cancer and aging-related diseases
Other features of the toroidal pores include ion selectivity and discrete size (Yeaman and Yount, 2003)
Kawamata, M., Suzuki, H., Kimura, R