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This is normal pharmacological tolerance, and it is one reason these medications use a dose escalation schedule rather than starting at the maximum

doi:10.1503/cmaj.080727

Among factors that cause a decline in glutathione levels are the aging process, stress, and poor diet

Falkai P, Rossner MJ, Schulze TG, Hasan A, Brzzka MM, Malchow B, et al

Once ingested, it is rapidly deacetylated by the body to yield free cysteine, completely bypassing the metabolic bottlenecks that often plague chronically ill patients

Its to restore your cells ability to produce energy efficiently, repair damage effectively, and respond to stress appropriately