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Persistent senescent cells can propagate the senescent phenotype, resulting in blood-brain barrier breakdown, infiltration of systemic immune cells, neurodegeneration, and gliosis, all of which are observed in the context of AD

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However, there is currently no validated blood-based or imaging biomarker that can reliably diagnose CHE

3a) using one-way or two-way ANOVA or mixed-effects analysis with Tukeys or Sidaks multiple comparison analysis

It enhances metalloproteinase activity, which breaks down damaged collagen so new, properly organized collagen can replace it

The salvage pathway helps maintain the adenine nucleotide pool in cells