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Interestingly, research on clonal pancreatic -cells revealed that fatty acid load stimulated GIPR expression via the activation of PPAR- transcriptional factor under normoglycemia (99 mg/dL), but not during hyperglycemia (450 mg/dL) (59)

The most common side effects were nausea, diarrhea, and fatigue

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The incretin effect is significantly impaired in people with T2D, greatly reducing the capacity for insulin release in response to food intake [8]

Second Nature is an all-in-one service: it prescribes Mounjaro or Wegovy, delivers the medication, and provides dietitian-led coaching alongside a structured behaviour change programme

It does this by targeting certain receptors in the brain that regulate hunger and satiety